PHARMACOLOGICAL TREATMENT OF DERMATOPHYTOSES: A REVIEW

Resumo

Introduction: Dermatophytoses, commonly known as "ringworms," are common fungal skin infections caused by a group of fungi called dermatophytes, which affect the skin, hair, and nails of a significant portion of the global population. Objective: This study aims to conduct a literature review on the main pharmacological classes and drugs used in the treatment of ringworm infections. Methodology: This is a narrative review where articles published between 2013 and 2023 were searched in the Lilacs, Scielo, and PubMed databases, with a preference for publications in English. Results: The main drugs used for the treatment of ringworm infections include fluconazole, ketoconazole, itraconazole, miconazole, clotrimazole, terbinafine, griseofulvin, and amorolfine. Additionally, the primary mechanisms of resistance to commercially available antifungal drugs against dermatophytoses were mainly enzymatic overexpression and alterations in permeability. In this context, numerous molecules with anti-dermatophyte potential have been studied, with luliconazole standing out. Conclusion: Despite advances in treatment, challenges such as fungal resistance and the need for personalized approaches persist. Collaboration among dermatologists, mycologists, and pharmacists is essential to optimize therapeutic outcomes and improve the quality of life of patients affected by dermatophytoses.